Fig. 4.

Model of CCN2. The model of the 4 domains of CCN2 is shown in ribbon and surface representations arranged in N- to C- termini from top to bottom. The linker regions with their variable sequence and flexible nature could not be modelled and it is unknown if there are intra-domain interactions about a hinge. Unlike the others the CT domain of CCN2 has a predicted short α-helix in place of a β-strand. This figure was adapted from Holbourn et al (2008) with permission from the authors