Table 4.

Endothelial markers before treatment, during treatment and after discontinuation of bosentan

	s-VCAM-1 (ng/ml)	TM (ng/ml)	vWF (%)
Before treatment	289 ± 83	4.8 ± 4.2	66 ± 57
Week 4	304 ± 110	4.5 ± 2.7	151 ± 86*
Week 8	292 ± 94	4.3 ± 3.2	101 ± 76
Week 12	291 ± 94	2.1 ± 3.3*	96 ± 103
Week 16	282 ± 76	2.7 ± 2.4*	95 ± 93
Week 20	282 ± 92	3.2 ± 3.7*	147 ± 78*,**

Values are expressed as mean ± standard deviation

s-VCAM-1 serum vascular cellular adhesion molecule-1, TM thrombomodulin, vWF von Willebrand factor

^*p < 0.05 compared to baseline; ^**p < 0.05 compared to week 16