Fig. 2.

Activation of P2X₇ receptor in cortical and hippocampal astrocytes. a Kinetics of [Ca²⁺]_i changes in hippocampal (left) and cortical (right) cultures upon prolonged exposure to 100 μM BzATP. Note the long-lasting [Ca²⁺]_i increase induced by BzATP in cortical but not hippocampal astrocytes. b Quantitative analysis of peak and area under curve of BzATP-induced [Ca²⁺]_i rises in astrocytes from rat hippocampus or cortex. c BzATP-induced [Ca²⁺]_i responses in the presence or in the absence of P2X antagonists or calcium ions in cortical cultures. d Representative traces of [Ca²⁺]_i changes evoked by BzATP in the absence or in the presence of extracellular calcium ions in hippocampal astrocytes