Best-fit piecewise linear regression models for hemodynamic changes in the anterior intracranial circulation at the carotid fork region. There were significant piecewise linear models for the relationship of the middle cerebral artery (MCA) (p<0.0001, R2=63%) (A), anterior cerebral artery (ACA) (p<0.0001, R2=52.60%) (B), and terminal intracranial artery (p=0.0001, R2=42.70%) (C) with the knot point at stage III.