Table 1. Description of Bartonella henselae isolates and strains tested, global diversity of the typing system, and diversity variations according to 16S rDNA genotype, continent, and host*.
| Characteristics | No. isolates/ strains | No. profiles | Average no. isolates/profiles | DI | No. alleles (minimum–maximum no. repeats) |
||||
|---|---|---|---|---|---|---|---|---|---|
| A | B | C | D | E | |||||
| All B. henselae | 178 | 99 | 1.8 | 0.98 | 8 (9–16) | 22 (5–37) | 14 (1–25) | 8 (1–9) | 7 (1–7) |
| 16S rDNA genotype I | 64 | 44 | 1.5 | 0.98 | 6 | 12 | 11 | 6 | 6 |
| 16S rDNA genotype II |
114 |
55 |
2.0 |
0.97 |
6 |
15 |
7 |
7 |
6 |
| Location | |||||||||
| Europe | 80† | 42 | 1.9 | 0.95 | 6 | 12 | 6 | 6 | 5 |
| Asia | 29‡ | 22 | 1.3 | 0.98 | 7 | 10 | 8 | 4 | 3 |
| USA | 49§ | 28 | 1.7 | 0.95 | 4 | 12 | 7 | 6 | 6 |
| Australia–New Zealand |
20¶ |
11 |
1.8 |
0.87 |
4 |
5 |
5 |
4 |
6 |
| Host | |||||||||
| Human + dog | 22# | 12 | 1.8 | 0.87 | 2 | 6 | 6 | 3 | 6 |
| Healthy cat | 156 | 92 | 1.7 | 0.98 | 8 | 20 | 11 | 8 | 7 |
*DI, diversity index; A, BHV-A; B, BHV-B; C, BHV-C; D, BHV-D; E, BHV-E. †Denmark, 18 (7); France, 23 (7); Germany, 27 (2); UK, 12 (5). ‡Japan, 12 (8); Philippines, 7 (9); Thailand, 10 (10). §California: 36, including 5 owners and their 11 cats (6,14); North Carolina, 12 (provided by Ed Breitschwerdt). Reference strain Houston 1. ¶Australia, 18 and New Zealand, 2 (3,12). #21 human isolates from 1 German patient with bacillary angiomatosis (BA) (2), 1 Japanese patient with cat-scratch disease (provided by S. Maruyama), 12 Australian human patients with cat-scratch disease (3), 5 California human patients with BA (14), 1 North Carolina patient with a wide range of symptoms, including fatigue, joint pain, insomnia, headache, blurred vision, irritability (provided by Ed Breitschwerdt), plus the reference strain Houston 1 (ATCC 49882, initially isolated from a patient with BA) (3), and 1 isolate from a dog with endocarditis (provided by Ed Breitschwerdt).