Table. Results of genetic screening for single nucleotide polymorphisms known to be associated with sepsis severity in patient with Plasmodium malariae infection, France*.
| Gene | rs | Wild type | Heterozygous | Homozygous |
|---|---|---|---|---|
| Pathogen detection | ||||
| TLR2 | 5743708 | X | ||
| TLR2 | 5743704 | X | ||
| TLR4 | 4986790 | X | ||
| TLR5 | 5744168 | X | ||
| CD14 | 2569190 | X | ||
| MD-2 | –1625C/G | X | ||
| FcγRIIa | 1801274 | X | ||
| MBL2 | 52 A/D | X | ||
| MBL2 | 54 A/B | X | ||
| MBL2 | 57 A/C | X | ||
| MBL2 | –550 H/L | X | ||
| MBL2 | –221 X/Y | X | ||
| MBL2 |
+4 P/Q |
X |
|
|
| TLR signaling | ||||
| IRAK1 | 1059703 | X | ||
| TIRAP | 8177374 | X | ||
| IκB | 3138053 | X | ||
| IκB |
2233406 |
|
X |
|
| Inflammation | ||||
| Lymphotoxin α | 909253 | X | ||
| TNF α | 1800629 | X | ||
| ACE | 17236674 | X | ||
| MIF | 755622 | X | ||
| IL-6 | 1800795 | X | ||
| IL-10 |
1800896 |
X |
|
|
| Coagulation | ||||
| PAI-1 | 1799768 | X | ||
| Factor V | 6025 | X |
*Except for MD-2 and MBL2, rs is the nomenclature used to describe the variants (initially described by den Dunnen and Antonarakis [4]). TLR, toll-like receptor; MBL2, mannose-binding lectin 2; IRAK-1, interleulin-1 receptor-associated kinase; TIRAP, toll interleukin-1 receptor-associated protein; IκB:, inhibitor of Nf-κB; TNF, tumor necrosis factor; ACE, angiotensin-converting enzyme; MIF, macrophage migration inhibitory factor; IL, interleukin; PAI-1, plaminogen activator inhibitor-1.