FIGURE 1.

Neural circuitry of OCD and DBS target. Hyperactivity in the CT loop or hypoactivity of the C-S-T-C loop may produce OCD symptoms. DBS targets the C-T loop and normalizes activity in the circuit.

KEY:

PFC:

prefrontal cortex

OFC:

orbitofrontal cortex

C-T:

corticothalmic

C-S-T-C:

cortico-striatal-thalamic-cortical

ACG:

anterior cingulate gyrus

OCD:

obsessive compulsive disorder

DBS:

deep brain stimulation