TABLE 3.
Cephalosporin | MSSA ATCC 25923
|
MRSA ATCC 33591
|
Decrease in MRSA MIC/MSSA MIC ratio | MRSA MIC/MSSA MIC ratio at pH 5.5 | ||||
---|---|---|---|---|---|---|---|---|
MIC (mg/liter)
|
pH-induced MIC decrease (fold) | MIC (mg/liter)
|
pH-induced MIC decrease (fold) | |||||
pH 7.4 | pH 5.5 | pH 7.4 | pH 5.5 | |||||
Cephalexin | 2 | 1 | 2 | 256 | 16 | 16 | 8 | 16 |
Cefuroxime | 2 | 0.125 | 16 | 128 | 1 | 128 | 8 | 4 |
Cefoxitin | 1 | 0.25 | 4 | 512 | 1 | 512 | 128 | 4 |
Ceftriaxone | 2 | 0.125 | 16 | 512 | 1 | 512 | 32 | 4 |
Ceftobiprole | 0.5 | 0.25 | 2 | 2 | 0.5 | 4 | 2 | 2 |