FIG. 4.
Pharmacokinetics of MPK1 and MPK6 in mice. Phage samples (5 × 107 PFU in PBS) of either MPK1 (○ and •) (A to C) or MPK6 (□ and ▪) (D to F) were administered i.p. (closed symbols) or i.m. (open symbols) to uninfected mice. Groups of mice (n = 3) were sacrificed at 0.5, 12, 24, 36, and 48 h postinfection; blood (A and D), liver (B and E), and lung (C and F) were extracted, and their homogenates were used to measure the PFU per unit volume (ml) as described in Materials and Methods. The PFU/ml is shown on a log scale.