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Inhibitory potencies of MK-4965, NVP, EFV, and ETV against WT, K103N, and Y181C RTs
| Compound | IC50 (nM)a
|
||
|---|---|---|---|
| WT | K103N | Y181C | |
| MK-4965 | 0.23 ± 0.09 (136) | 0.40 ± 0.15 (148) | 0.39 ± 0.16 (143) |
| EFV | 0.42 ± 0.06 (5) | 10.2 ± 6.6 (4) | 0.31 ± 0.17 (5) |
| NVP | 137 ± 5.8 (3) | 9300 ± 500 (3) | 8900 ± 1800 (3) |
| ETV | 0.60 ± 0.12 (4) | 1.3 ± 0.17 (4) | 1.96 ± 0.9 (3) |
IC50s are means ± standard deviations. Numbers in parentheses indicate the number of assays performed.
