TABLE 2.
Antiviral activities of MK-4965, EFV, NVP, and ETV against WT virus and viruses with K103N, Y181C, and K103N-Y181C mutations in the presence of 10% FBS and 50% NHS
| Additive and compound | EC95 (nM)a
|
|||
|---|---|---|---|---|
| WT | K103N | Y181C | K103N-Y181C | |
| 10% FBS | ||||
| MK-4965 | 4.4 ± 2.0 (80) | 13 ± 6 (80) | 30 ± 8.3 (24) | 128 ± 47 (20) |
| EFV | 3.8 ± 1.4 (69) | 245 ± 90 (55) | 8.4 ± 2.6 (17) | 322 ± 83 (15) |
| NVP | 438 ± 106 (4) | >8,000 | >8,000 | >8,000 |
| ETV | 4.0 ± 1.1 (10) | 6.0 ± 2.8 (8) | 26 ± 12 (8) | 56 ± 15 (8) |
| 50% HS | ||||
| MK-4965 | 29 ± 12 (78) | 58 ± 24 (24) | 184 ± 60 (21) | 447 ± 26 (7) |
| EFV | 38 ± 12 (70) | 1734 ± 322 (7) | 89 ± 19 (13) | 3394 ± 593 (8) |
| NVP | 464 ± 91 (4) | >8,000 | >8,000 | >8,000 |
| ETV | 38 ± 14 (8) | 43 ± 15 (10) | 266 ± 42 (9) | 542 ± 82 (7) |
a
EC95s are means ± standard deviations. Numbers in parentheses indicate the number of assays performed.