TABLE 4.
Changes in inhibitory potencies of NNRTIs and NRTIs against viruses containing resistance mutations to NRTIs, PIs, and both NRTIs and PIs
| Mutant virus | Fold change in potency compared with that against adrug-sensitive straina
|
||||
|---|---|---|---|---|---|
| 3TC | TDF | EFV | NVP | MK-4965 | |
| NRTI resistant (n = 4) | >103 | 1.97 ± 0.56 | 0.38 ± 0.09 | 0.49 ± 0.18 | 0.30 ± 0.07 |
| PI resistant (n = 6) | 1.15 ± 0.29 | 0.82 ± 0.15 | 0.90 ± 0.42 | 1.05 ± 0.5 | 0.84 ± 0.4 |
| NRTI and PI resistant (n = 7) | 5.96 ± 2.4a | 2.43 ± 2.41 | 0.2 ± 0.06 | 0.32 ± 0.15 | 0.18 ± 0.06 |
a
Four of seven viruses displayed >100-fold shifts.