TABLE 2.

In vitro and in vivo activities of all CFHCS hits

IDI no.	CFHCS IC50 (μM)	VARa	P. falciparum IC50 (μM)
			3D7	Dd2
1	338	1.3/1	3	6
7	236	1.4/1	3	6
11	182	NA	9	8
13	65	NA	4	6
17	158	NA	0	0
19	279	NA	14	16
30	22	NA	6	8
31	41	NA	12	9
40	30	NA	5	6
43	41	NA	1	2
48	36	NA	10	11
50	30	NA	15	10
52	219	315/40	8	5
57	102	NA	13	10
66	238	NA	0	0
70	111	NA	6	19
71	215	NA	13	16

^aCalculated for a parasite cytosol pH value of 7.3 and food vacuole pH values of 4.8 (10) and 5.7 (5) (values before and after the slash, respectively). NA, no accumulation.