TABLE 3.
Drug combination | Species | Isolate no. | Decrease in log10 CFU/ml (mean ± SD) at:
|
Effect of combinationb | |||
---|---|---|---|---|---|---|---|
2 h | 4 h | 8 h | 24 h | ||||
CPT + AMK | E. coli | 5401 | 1.01 ± 0.00 | 4.78 ± 0.08 | 5.30 ± 0.08 | 5.32 ± 0.02 | S |
5411 | 0.93 ± 0.80 | 2.88 ± 0.32 | 5.10 ± 0.06 | 5.98 ± 0.37 | S | ||
K. pneumoniae | 5427 | 0.65 ± 0.24 | 3.42 ± 0.08 | 4.43 ± 0.38 | 4.81 ± 0.34 | S | |
5436 | 0.26 ± 0.36 | 0.87 ± 0.14 | 3.31 ± 0.01 | 5.31 ± 0.14 | S | ||
E. cloacae | 4073 | 1.38 ± 0.01 | 1.68 ± 0.01 | 3.19 ± 0.16 | 4.65 ± 0.02 | S | |
5420 | 0.02 ± 0.02 | 1.12 ± 0.80 | 3.27 ± 0.36 | 4.44 ± 0.72 | S | ||
P. aeruginosa | 796 | 0.07 ± 0.05 | 0.63 ± 0.31 | 2.14 ± 0.41 | 5.23 ± 0.32 | S | |
956 | 0.36 ± 0.05 | 2.61 ± 0.02 | 2.66 ± 0.50 | 3.60 ± 0.44 | S | ||
1019 | 0.16 ± 0.11 | 1.32 ± 0.07 | 3.84 ± 0.81 | 0.67 ± 0.28 | I | ||
1037 | 0.09 ± 0.08 | 2.13 ± 0.07 | 2.71 ± 0.30 | 3.51 ± 0.27 | S | ||
CPT + TAZ | E. coli | 5401 | 0.94 ± 0.26 | 2.00 ± 0.02 | 3.37 ± 0.17 | 4.99 ± 0.09 | S |
5411 | 0.66 ± 0.18 | 2.43 ± 0.09 | 3.79 ± 0.01 | 6.02 ± 0.04 | S | ||
K. pneumoniae | 5427 | 1.13 ± 0.02 | 2.78 ± 0.16 | 4.89 ± 0.28 | 5.27 ± 0.50 | S | |
5436 | 0.48 ± 0.07 | 2.92 ± 0.14 | 5.31 ± 0.05 | 5.62 ± 0.56 | S | ||
E. cloacae | 4073 | 0.57 ± 0.13 | 0.65 ± 0.08 | 0.83 ± 0.09 | 0.47 ± 0.04 | I | |
5420 | 0.14 ± 0.38 | 0.43 ± 0.18 | 0.29 ± 0.08 | 0.46 ± 0.04 | I | ||
P. aeruginosa | 796 | 0.12 ± 0.28 | 0.32 ± 0.28 | 0.08 ± 0.01 | 0.31 ± 0.06 | I | |
956 | 0.08 ± 0.08 | 0.01 ± 0.08 | 0.51 ± 0.27 | 0.52 ± 0.13 | I | ||
1019 | 0.02 ± 0.50 | 0.43 ± 0.47 | 0.95 ± 0.09 | 1.22 ± 0.09 | I | ||
1037 | 0.01 ± 0.19 | 0.06 ± 0.16 | 0.73 ± 0.07 | 0.56 ± 0.24 | I | ||
CPT + MEM | E. coli | 5401 | 0.87 ± 0.20 | 3.12 ± 0.14 | 4.20 ± 0.72 | 4.93 ± 0.75 | S |
5411 | 0.08 ± 0.58 | 1.78 ± 0.15 | 3.91 ± 0.13 | 4.17 ± 0.47 | S | ||
K. pneumoniae | 5427 | 0.06 ± 0.13 | 1.13 ± 0.46 | 0.12 ± 0.05 | 0.12 ± 0.03 | I | |
5436 | 0.59 ± 0.05 | 1.16 ± 0.15 | 3.66 ± 0..32 | 0.04 ± 0.12 | I | ||
E. cloacae | 4073 | 0.86 ± 0.13 | 1.39 ± 0.28 | 1.21 ± 0.09 | 0.72 ± 0.20 | I | |
5420 | 0.10 ± 0.02 | 1.03 ± 0.73 | 1.44 ± 0.74 | 0.12 ± 0.11 | I | ||
P. aeruginosa | 796 | 0.07 ± 0.08 | 0.03 ± 0.04 | 0.05 ± 0.03 | 0.14 ± 0.16 | I | |
956 | 0.02 ± 0.03 | 0.21 ± 0.27 | 0.10 ± 0.01 | 0.31 ± 0.31 | I | ||
1019 | 0.01 ± 0.01 | 0.27 ± 0.10 | 0.04 ± 0.05 | 0.05 ± 001 | I | ||
1037 | 0.20 ± 0.04 | 0.32 ± 0.27 | 0.28 ± 0.15 | 1.71 ± 0.14 | I | ||
CPT + ATM | E. coli | 5401 | 0.32 ± 0.06 | 1.36 ± 0.01 | 0.12 ± 0.05 | 0.08 ± 0.01 | I |
5411 | 0.63 ± 0.25 | 0.99 ± 0.04 | 0.16 ± 0.03 | 0.33 ± 0.08 | I | ||
K. pneumoniae | 5427 | 0.01 ± 0.07 | 0.64 ± 0.02 | 0.06 ± 0.08 | 0.02 ± 0.09 | I | |
5436 | 0.44 ± 0.01 | 0.37 ± 0.02 | 2.00 ± 0.09 | 0.14 ± 0.07 | I | ||
E. cloacae | 4073 | 0.69 ± 0.32 | 1.71 ± 0.25 | 1.73 ± 0.29 | 3.08 ± 0.13 | I | |
5420 | 0.03 ± 0.04 | 0.90 ± 0.88 | 3.33 ± 0.91 | 2.99 ± 0.12 | I | ||
P. aeruginosa | 796 | 0.06 ± 0.11 | 0.04 ± 0.26 | 0.97 ± 0.18 | 0.85 ± 0.15 | I | |
956 | 0.18 ± 0.15 | 0.12 ± 0.17 | 0.20 ± 0.53 | 0.73 ± 0.68 | I | ||
1019 | 0.03 ± 0.05 | 0.15 ± 0.22 | 0.15 ± 0.03 | 0.26 ± 0.27 | I | ||
1037 | 0.17 ± 0.09 | 0.12 ± 0.36 | 0.22 ± 0.16 | 1.01 ± 0.54 | I | ||
CPT + LEV | E. coli | 5401 | 0.11 ± 0.11 | 1.00 ± 0.21 | 0.05 ± 0.02 | 0.04 ± 0.06 | I |
5411 | 0.63 ± 0.58 | 0.58 ± 0.01 | 0.08 ± 0.14 | 0.01 ± 0.05 | I | ||
K. pneumoniae | 5427 | 0.15 ± 0.05 | 0.18 ± 0.07 | 1.68 ± 0.22 | 1.70 ± 0.20 | I | |
5436 | 0.09 ± 0.07 | 1.05 ± 0.09 | 0.47 ± 0.08 | 0.08 ± 0.01 | I | ||
E. cloacae | 4073 | 0.10 ± 0.07 | 0.24 ± 0.02 | 0.10 ± 0.02 | 0.16 ± 0.01 | I | |
5420 | 0.01 ± 0.10 | 0.41 ± 0.38 | 0.05 ± 0.14 | 0.04 ± 0.06 | I | ||
P. aeruginosa | 796 | 0.03 ± 0.02 | 0.21 ± 0.42 | 0.35 ± 0.09 | 0.04 ± 0.14 | I | |
956 | 0.08 ± 0.09 | 0.25 ± 0.23 | 0.14 ± 0.00 | 0.98 ± 0.06 | I | ||
1019 | 0.21 ± 0.15 | 0.03 ± 0.01 | 1.21 ± 0.13 | 0.00 ± 0.00 | I | ||
1037 | 0.02 ± 0.10 | 0.10 ± 0.15 | 0.04 ± 0.01 | 0.10 ± 0.36 | I | ||
CPT + CPM | E. coli | 5401 | 0.37 ± 0.04 | 1.54 ± 0.12 | 0.04 ± 0.01 | 0.03 ± 0.02 | I |
5411 | 0.56 ± 0.51 | 0.38 ± 0.01 | 0.07 ± 0.00 | 0.01 ± 0.00 | I | ||
K. pneumoniae | 5427 | 0.08 ± 0.03 | 0.82 ± 0.19 | 0.38 ± 0.32 | 0.20 ± 0.30 | I | |
5436 | 0.01 ± 0.07 | 0.51 ± 0.11 | 0.16 ± 0.06 | 0.31 ± 0.01 | I | ||
E. cloacae | 4073 | 0.17 ± 0.12 | 0.57 ± 0.14 | 0.55 ± 0.14 | 0.03 ± 0.02 | I | |
5420 | 0.41 ± 0.33 | 0.12 ± 1.09 | 0.03 ± 0.06 | 0.07 ± 0.11 | |||
P. aeruginosa | 796 | 0.02 ± 0.04 | 0.27 ± 0.30 | 0.08 ± 0.01 | 0.02 ± 0.01 | I | |
956 | 0.25 ± 0.24 | 0.01 ± 0.19 | 0.35 ± 0.37 | 0.52 ± 0.38 | I | ||
1019 | 0.13 ± 0.11 | 0.08 ± 0.08 | 0.03 ± 0.01 | 0.05 ± 0.29 | I | ||
1037 | 0.52 ± 0.18 | 1.17 ± 0.19 | 1.66 ± 0.47 | 1.81 ± 0.41 | I | ||
CPT + TIG | E. coli | 5401 | 0.12 ± 0.08 | 0.45 ± 0.78 | 0.02 ± 0.11 | 0.13 ± 0.07 | I |
5411 | 0.23 ± 0.11 | 0.17 ± 0.09 | 0.08 ± 0.15 | 0.01 ± 0.02 | I | ||
K. pneumoniae | 5427 | 0.32 ± 0.07 | 0.59 ± 0.02 | 0.62 ± 0.59 | 0.25 ± 0.31 | I | |
5436 | 0.13 ± 0.16 | 0.40 ± 0.52 | 0.22 ± 0.17 | 0.03 ± 0.02 | I | ||
E. cloacae | 4073 | 0.05 ± 0.06 | 0.43 ± 0.00 | 0.95 ± 0.00 | 0.14 ± 0.03 | I | |
5420 | 0.13 ± 0.11 | 0.15 ± 0.11 | 0.08 ± 0.08 | 0.10 ± 0.12 | I | ||
P. aeruginosa | 796 | 0.05 ± 0.03 | 0.48 ± 0.08 | 0.01 ± 0.03 | 0.17 ± 0.28 | I | |
956 | 0.12 ± 0.06 | 0.22 ± 0.28 | 0.28 ± 0.07 | 0.33 ± 0.38 | I | ||
1019 | 0.00 ± 0.02 | 0.10 ± 0.11 | 0.11 ± 0.01 | 0.14 ± 0.16 | I | ||
1037 | 0.10 ± 0.03 | 0.06 ± 0.31 | 1.07 ± 0.25 | 0.54 ± 0.12 | I |
The starting inoculum used was ∼106 CFU/ml. Abbreviations: CPT, ceftaroline; AMK, amikacin; TAZ, tazobactam; MEM, meropenem; ATM, aztreonam; LEV, levofloxacin; CPM, cefepime; TIG, tigecycline.
S, synergy; I, indifference.