TABLE 3.

Effects of anidulafungin-voriconazole combination on serum creatinine, serum urea nitrogen, serum ALT, serum AST, and potassium concentrations in persistently neutropenic rabbits with pulmonary aspergillosis^a

Treatment group (n)	Serum creatinine concn (mg/dl)	Serum urea nitrogen concn (mg/dl)	Serum ALT concn (U/liter)	Serum AST concn (U/liter)	Serum potassium concn (mmol/liter)
Controls (14)	1.67 ± 0.57	33.2 ± 9.86†	45.2 ± 13.5†	71.4 ± 28.5†	3.20 ± 0.21
VRC (12)	1.02 ± 0.06	12.8 ± 1.49	22.2 ± 5.52	26.8 ± 6.98	3.17 ± 0.32
AFG5 (9)	1.50 ± 0.24*	29.8 ± 9.42*	22.2 ± 3.65*	34.3 ± 5.78*	2.82 ± 0.13
AFG5+VRC (10)	0.98 ± 0.08*	11.8 ± 1.20*†	11.8 ± 1.40*†	13.2 ± 3.37*†	3.90 ± 0.08
AFG10 (11)	1.34 ± 0.25	22.4 ± 2.54*	39.4 ± 7.22*	48.3 ± 15.4	3.45 ± 0.22
AFG10+VRC (11)	0.94 ± 0.07	15.4 ± 1.86*†	19.2 ± 3.57*	16.0 ± 4.04	3.54 ± 0.35

^aAll values are expressed as means ± SEM. *, for comparison between combination therapy and monotherapy, P < 0.05 (Mann-Whitney U test); †, for comparison between combination therapy and controls, P < 0.05 (Mann-Whitney U test).