TABLE 1.
Averages and between-subject coefficients of variation (percent) calculated from individual PK parameter estimatesa
| Drug and program | CLb (liter h−1) | Vcentralb (liters) | Vperipheralb (liters) | CLicb (liter h−1) | t1/2,equilibrationc,d (min) | Fcorticalc | Fcancellousc |
|---|---|---|---|---|---|---|---|
| Amoxicillin | |||||||
| NONMEM | 12.4 (19)e | 11.3 (12) | 6.17 (3.7) | 11.1 (19) | 11.8 | 0.199 (11) | 0.192 (39) |
| S-ADAPT | 12.0 (15) | 11.3 (9.8) | 6.14 (3.1) | 11.2 (17.6) | 11.1 (4.4) | 0.210 (30) | 0.204 (49) |
| Clavulanic acid | |||||||
| NONMEM | 11.0 (6.2) | 16.7 (25) | 14 | 0.156 (17) | 0.119 (57) | ||
| S-ADAPT | 11.0 (6.6) | 16.2 (22) | 21.4 (12) | 0.188 (34) | 0.147 (61) |
a
The Vbone was fixed to 0.177 liter for amoxicillin and to 0.172 liter for clavulanic acid (see Materials and Methods for details).
b
An informative prior was used.
c
An uninformative but physiologically plausible prior was used.
d
t1/2,equilibration, half-life of equilibration between serum and bone.
e
Values in parentheses are the between-subject coefficients of variation (in percent).