TABLE 3.
Comparison of the expectation value for target attainment against MSSA and S. epidermidis (28) for amoxicillina
| Compartment and dosing interval (h) | Expected value (%) for the indicated target values of fT>MIC
|
|||||||
|---|---|---|---|---|---|---|---|---|
| MSSA (n = 196)
|
S. epidermidis (n = 119)
|
|||||||
| 30% | 50% | 70% | 100% | 30% | 50% | 70% | 100% | |
| Serum | ||||||||
| 4 | 99.5 | 97.2 | 96.2 | 95.4 | 99.7 | 97.9 | 96.1 | 90.5 |
| 6 | 97.2 | 96.0 | 95.1 | 86.9 | 98.0 | 95.1 | 87.6 | 68.0 |
| 8 | 96.4 | 95.3 | 90.4 | 58.9 | 96.8 | 89.4 | 73.1 | 45.3 |
| Cortical bone | ||||||||
| 4 | 95.7 | 95.3 | 94.4 | 88.3 | 93.4 | 87.2 | 77.8 | 63.5 |
| 6 | 95.3 | 93.6 | 83.2 | 47.4 | 87.7 | 72.9 | 57.4 | 38.0 |
| 8 | 94.8 | 86.5 | 56.4 | 17.7 | 80.9 | 60.3 | 42.0 | 22.2 |
| Cancellous bone | ||||||||
| 4 | 95.6 | 95.1 | 93.5 | 84.5 | 91.5 | 84.4 | 75.3 | 61.1 |
| 6 | 95.1 | 92.0 | 78.9 | 44.3 | 85.1 | 70.4 | 55.4 | 36.9 |
| 8 | 94.2 | 81.8 | 52.1 | 16.5 | 77.9 | 57.7 | 40.6 | 20.9 |
a
Simulations are based on the estimates from NONMEM (Table 1) and a 30-min infusion of 2,000 mg amoxicillin and 200 mg clavulanic acid at steady state.