TABLE 1.
Effect of HDP-(S)-HPMPA and ODE-(S)-HPMPA on HCV replication in vitro
| Compounda | EC50 (μM) | CC50 (μM) | Selectivity (CC50/EC50) |
|---|---|---|---|
| BM4-5 FEO, genotype 1B | |||
| (S)-HPMPA | >100 | >100 | |
| (R)-HPMPA | >100 | >100 | |
| ODE-(S)-HPMPA (4) | 1.31 ± 0.66 | 35.6 ± 6.8 | 27 |
| ODE-(R)-HPMPA (4) | 7.0 ± 8.21 | >100 | >14 |
| HDP-(S)-HPMPA (4) | 2.02 ± 0.95 | 85.3 ± 6.8 | 42 |
| HDP-(R)-HPMPA (4) | 6.71 ± 2.95 | >100 | >15 |
| SGR-JFH-1 FEO, genotype 2A | |||
| (S)-HPMPA | >100 | >100 | |
| (R)-HPMPA | >100 | >100 | |
| ODE-(S)-HPMPA (4) | 0.69 ± 0.71 | 35.6 ± 6.8 | 52 |
| ODE-(R)-HPMPA (4) | 26.7 ± 14.3 | >100 | >4 |
| HDP-(S)-HPMPA (4) | 6.5 ± 12.5 | 85.3 ± 20.8 | 13 |
| HDP-(R)-HPMPA (4) | 41.0 ± 3.61 | >100 | >2 |
a
Data are the means ± standard deviations. The number in parentheses is the number of replicate determinations.