TABLE 3.
The dose-dependent activity of DL5 for treatment of abdominal infection with S. aureus Smitha
| Peptide (μg/mouse) | Survival of mice
|
|
|---|---|---|
| Day 5 | %b | |
| Vehicle | 0/4 | 0 |
| DL5 (3.13) | 0/4 | 0 |
| DL5 (12.5) | 0/4 | 0 |
| DL5 (25) | 3/4 | 75* |
| DL5 (50) | 7/8 | 87.5** |
| DL5 (100) | 3/4 | 75* |
a
The minimum lethal dose of S. aureus Smith (2 × 106 CFU/mouse) was inoculated by intraperitoneal injection after treatment with DL5 for 7 h.
b
Statistical analysis was carried out by Fisher's exact test (*, P < 0.05; **, P < 0.01; ***, P < 0.001).