TABLE 2.
Parameter estimates for the final population modela
| Parameter | Value (95% CI) | Variability (%) |
|---|---|---|
| Oral clearance (liters/h) | 22.0 (19.8-24.4) | IIV, 3.55; BOV, 16.4 |
| Vol of distribution (liters) | 41.5 (34.0-50.6) | IIV, 21.2 |
| Ka (h−1) | 0.407 (0.363-0.428) | IIV, 12.73 |
| Tlag (h) | 0.695 (0.349-0.754) | |
| Relative bioavailability for: | ||
| 250-500 mg | 1.0 | |
| 1,000 mg | 0.616 (0.465-0.722) | |
| 1,500-2,000 mg | 0.439 (0.353-0.510) |
a
Abbreviations: CI, confidence interval; Tlag, absorption time lag; IIV, intraindividual variability; BOV, between-occasion variability (expressed as coefficient of variation).