FIG. 4.

Growth inhibition of intracellular S. Typhimurium relies on omeprazole (Omep) application at early stages of infection. S. Typhimurium 14028 begins to show intracellular replication in RAW264.7 cells at 8 h postinfection. The application of omeprazole before this time point results in the substantial inhibition of the intracellular growth yield as measured at 16 h postinfection. The statistical difference between the growth yields was confirmed in a paired student's t test (*, P < 0.05).