FIG. 5.

Intracellular replication of selected SPI2 mutants of S. Typhimurium 14028 in RAW264.7 cells reveals a residual SPI2-independent replication that is not affected by omeprazole (Omep). The increase in intracellular bacteria between 2 and 16 h postinfection in the absence or presence of omeprazole (at 200 μM) was determined by viable counting, and the ratio is displayed as the growth yield. The statistical difference between the growth yields was confirmed in a paired student's t test (*, P < 0.05; ***, P < 0.0005). WT, wild type.