TABLE 1.
Pharmacokinetics parameters at day 14 and trough concentrations over time for the FPV/r arma
| Parameter | n | Median | IQR |
|---|---|---|---|
| AUC(0-12) (ng · h/ml) | 31 | 35,370 | 26,622, 51,740 |
| C12 (ng/ml) | 2,060.00 | 1,300.00, 2,850.00 | |
| Cmax (ng/ml) | 4,970.00 | 3,960.00, 7710.00 | |
| Tmax (h) | 3.00 | 2.00, 6.00 | |
| Cτ (ng/ml) | |||
| Week 2 | 25 | 2,450 | 1,910, 3,100 |
| Week 4 | 21 | 2,330 | 1,780, 3,480 |
| Week 8 | 21 | 2,480 | 1,890, 3,740 |
| Week 24 | 20 | 2,020 | 1,475, 2,855 |
a
The longitudinal data for IDV and LPV are not shown due to the limited sample sizes for these arms. Pharmacokinetics data following FPV/r dosing refer to APV.