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. Author manuscript; available in PMC: 2010 Jun 15.
Published in final edited form as: Dev Biol. 2009 Apr 14;330(2):452–460. doi: 10.1016/j.ydbio.2009.04.009

Figure 4.

Figure 4

Sufu is epistatic to Ift88. (A–D) lateral views of E9.5 mouse embryos. Arrowheads in B point to elevated neural ridges in the brain of an Ift88 mutant embryo. Note that there is no neural ridge elevation in the brains of the Sufu (C) and Sufu/Ift88 double (D) mutant embryos. (E–H) Ptch1 expression in E9.5 whole embryos detected by wholemount RNA in situ hybridization. Ptch1 expression is reduced in an Ift88 mutant embryo (F), but upregulated in the Sufu (G) and Sufu/Ift88 double (H) mutant embryos. (I–J) Gli1 expression in E9.5 whole embryos detected by wholemount RNA in situ hybridization. Gli1 expression is reduced in an Ift88 mutant embryo (J), but upregulated in the Sufu (K) and Sufu/Ift88 double (L) mutant embryos