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. Author manuscript; available in PMC: 2010 Jun 15.
Published in final edited form as: Dev Biol. 2009 Apr 14;330(2):452–460. doi: 10.1016/j.ydbio.2009.04.009

Figure 6.

Figure 6

Sufu regulates spinal cord patterning downstream of Smo. (A) Nkx2.2 labels the precursors for V3 interneurons. (B) Pax6 is present in the neural progenitor cells of the dorsal two-thirds of the spinal cord. (C) Pax7 is present in the dorsal progenitor cells of the wild type spinal cord. (D) Nkx2.2 is absent in Smo mutants. (E) Pax6 is present throughout the spinal cord in Smo mutants. (F) Pax7 is present throughout the spinal cord in Smo mutants. (G) Nkx2.2 is present throughout the spinal cord of Sufu mutant. (H) Pax6 is absent in the Sufu mutant spinal cord. (I) Pax7 is absent in the Sufu mutant spinal cord. (J) Nkx2.2 is present throughout the spinal cord of Sufu/Smo double mutant. (K) Pax6 is absent in the Sufu/Smo double mutant spinal cord. (L) Pax7 is absent in the Sufu/Smo double mutant spinal cords. Shown are immunofluorescent images of transverse sections of E9.5 embryos. Dashed lines outline the spinal cord.