TABLE 3.
Competitive colonization on day 3 postinfectiona
| Location of colonization | Bacterial counts of indicated strain in luminal contents (log10 CFU/g)
|
P valueb | Bacterial counts of indicated strain in homogenized tissue (log10 CFU/g)
|
P valueb | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 042
|
042PicS258A
|
042
|
042PicS258A
|
|||||||
| Mean | Median | Mean | Median | Mean | Median | Mean | Median | |||
| Ileum | 4.5 ± 2.1 | 3.0 | ≤3.0 ± 0.0 | ≤3.0 | 1.0 | 3.7 ± 0.9 | 3.2 | ≤3.0 ± 0.0 | ≤3.0 | 1.0 |
| Cecum | 8.6 ± 0.5 | 8.5 | 5.5 ± 0.7 | 5.59 | 0.004 | 6.1 ± 1.1 | 5.7 | 3.1 ± 0.2 | 3.1 | 0.004 |
| Colon with mucus layer | 7.9 ± 1.1 | 8.1 | 4.7 ± 0.7 | 4.8 | 0.005 | 6.2 ± 0.9 | 6.3 | 3.4 ± 0.5 | ≤3.0 | 0.001 |
| Colonic mucus layer | 5.5 ± 0.9 | 5.4 | ≤3.0 ± 0.0 | ≤3.0 | 0.01 | 5.5 ± 0.9 | 5.5 | 3.1 ± 0.1 | ≤3.0 | 0.003 |
a
Five mice were given 1 × 103 CFU of strains 042 and 042PicS258A simultaneously. Numbers in the table are the means ± 1 standard deviation and median log10 CFU/g tissue or per milliliter of contents at 3 days postinfection. Limit of detection was approximately 1 × 103 CFU/g. If no organisms were detected, mean and median are recorded as ≤3.0 log10 CFU/g.
b
P values for the difference between the mean colonization of strains 042 and 042PicS258A for each site were determined by using the paired t test of log-transformed data. If none was detected, the P value is based on 3 log10 CFU/g.