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. 2009 Mar 16;77(6):2251–2261. doi: 10.1128/IAI.00068-09

FIG. 3.

FIG. 3.

YCV morphology in activated macrophages as determined by thin-section EM. BMDMs were infected with KIM5+ and then treated with IFN-γ. At 4 h (A to C) or 22 h (D to F) the cells were fixed and processed for thin-section EM. (A) BMDM infected with KIM5+ at 4 h postinfection. (B) Magnification of area containing bacteria in panel A. The arrow indicates a double membrane surrounding a single bacterium. (C) BMDM infected with KIM5+ at 4 h postinfection, showing two bacteria and other vesicles in a single-membrane compartment. (D) BMDM infected with KIM5+ for 22 h. The arrow indicates a region with a double membrane. (E) Magnification of a region in panel D. (F) BMDM infected with KIM5+ for 22 h. A region containing a double membrane is magnified in the inset. (A) Bar = 2 μm. (B to F) Bars = 500 nm.