FIG. 7.

Effects of DN mutants of rab4, rab7, and rab11 on FMDV infection of IBRS-2 cells. IBRS-2 cells were transfected to express wt or DN mutants of rab4, rab7, and rab11 and infected with FMDV. Cells expressing the rab protein were identified by the EGFP tag. FMDV-infected cells were identified as for Fig. 1. Cells expressing either the wt or DN rab were scored for infection. The data are shown as the percentage of the DN rab-expressing cell population that were infected normalized to the level of infection of cells expressing the corresponding wt rab protein. For rab4 and rab11 the results are the means ± standard deviations for three independent experiments. For rab7 the results are shown as the means for two independent experiments, each giving near-identical results.