FIG. 1.

Organization and structure of A-VP1. (A) Cartoon schematic illustrating the three-domain organization of A-VP1. The N-terminal domain is yellow, the C-terminal domain is pink, and the finger, palm, and thumb subdomains of the polymerase domain are pale blue, brick red, and green, respectively. The extreme C-terminal plug is cyan. (B) Ribbon representation of the A-VP1 apoenzyme crystal structure (PDB no. 2R7Q). (C) Ribbon representation of the “right-hand” A-VP1 polymerase domain. The colors in panels B and C correspond to those in panel A.