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Inhibition of JNK1/2 and p38 MAPK phosphorylation blocks PCV2 replication. Supernatants of PCV2-infected PK15 cells at 72 h after treatment with various concentrations of JNK inhibitor 1 (A) or SB202190 (B), as well as UV-irradiated PCV2-infected cell supernatants at 72 h, were inoculated on monolayers of PK15 cells. Virus production was assayed by ICS under a microscope. The values represent the means of results for three independent experiments; error bars indicate the SD.
