FIG. 6.

Inhibition of JNK1/2 and p38 MAPK phosphorylation reduces PCV2-induced caspase-3 activity. Whole-cell lysates harvested from PCV2-infected cells at 72 h after treatment with various concentrations of the JNK inhibitor 1 (A) or SB202190 (B), as well as UV-irradiated PCV2-infected cells at 72 h, were assayed for DEVDase activity using the caspase-3 colorimetric DEVD-AFC. In addition, cells infected with PCV2 alone were treated with the caspase-3 inhibitor DEVD-CHO. Mock-infected cells were used as a negative control. The values shown are means from duplicate experiments.