Table 1.
A comparison of hematologic parameters in phenotypically severe and mild α-thalassemia in the offspring of F1 129sv/ev/C57BL mice backcrossed to 129sv/ev
| Group | Genotype | n | Hb, g/dl | MCV, μm3 | MCH, pg | RDW, % | Retics, % |
|---|---|---|---|---|---|---|---|
| I (Severe) | |||||||
| α1−/− homozygotes | α1−α2/α1−α2 | 14 | 8.0 ± 0.6 | 31 ± 4.3 | 13.7 ± 1 | 41.3 ± 1.6 | 32 ± 5.5 |
| II (Mild) | |||||||
| α1−/− homozygotes | α1−α2/α1−α2 | 19 | 10.1 ± 0.8 | 33 ± 2.4 | 14.6 ± 1 | 34 ± 1.9 | 9.0 ± 4.0 |
| Wild type | |||||||
| 129 | α1α2/α1α2 | 4 | 15.3 ± 0.1 | 45 ± 0.3 | 15.2 ± 1 | 15 ± 2 | 1.9 ± 0.9 |
| Wild type | |||||||
| B6 | α1α2/α1α2 | 4 | 15.6 ± 0.5 | 46 ± 0.4 | 15.6 ± 0.3 | 12.6 ± 0.4 | 1.5 ± 0.1 |
MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; RDW, red cell distribution width; Retics, reticulocytes in peripheral blood; 129, 129sv/ev inbred mice; B-6, C57B1-6 inbred mice; backcrossed mice: product of α1−/+/(129/B6) × α1− 129/129. Values given are mean ± SD.