Table 2.
β-Globin and hematologic parameters in backcrossed α1-deficient mice of the 129sv/ev/BALB/c genetic background
| α1 mutation | β-globin alleles | n | Hb, g/dl | MCV, μm3 | MCH, pg | RDW, % | Retic, % |
|---|---|---|---|---|---|---|---|
| α1−/− homozygotes | 129/129 | 4 | 8.6 ± 0.9 | 34 ± 2.4 | 12.5 ± 1.3 | 41 ± 4.3 | 35 ± 4.1 |
| α1−α2/α1−α2) | |||||||
| α1−/− homozygotes | 129/BALB | 4 | 8.3 ± 0.5 | 37 ± 4.5 | 13 ± 0.8 | 40 ± 1 | 39 ± 2.5 |
| α1−α2/α1−α2 | |||||||
| Wild-type 129 | 129/129 | 4 | 15.6 ± 0.5 | 46 ± 0.4 | 15.6 ± 0.3 | 12.6 ± 0.4 | 1.5 ± 0.2 |
| α1α2/α1α2 | |||||||
| Wild-type BALB | BALB/BALB | 4 | 16.4 ± 0.3 | 49.5 ± 1.3 | 16.8 ± 0.3 | 15.9 ± 0.6 | 3.1 ± 0.8 |
| α1α2/α1α2 |
Abbreviations are as in Table 1. BALB, BALB/c inbred mice. Backcrossed mice: product of α1+/− (129/BALB) × α1+/− (129/129). The β-globin alleles were distinguished using PCR and D7Mit-40 oligonucleotides as primers. Values are mean ± SD.