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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Hematol Oncol Clin North Am. 2009 Jun;23(3):397–414. doi: 10.1016/j.hoc.2009.03.005

Table 1.

Summary of exemplary melanoma oncogenes

Gene Function Alteration Prevalence Discovery Method
NRAS Growth, Proliferation Mutation 15-30% Transformation assay, genotyping
BRAF Proliferation, Survival Mutation 50-70% Systematic DNA sequencing
MITF Lineage survival Amplification 10-20% Copy number and gene expression
profiling
NEDD9 Invasion, Metastasis Amplification 36% Copy number profiling and
evolutionary conservation
KIT Proliferation, Survival Mutation,
Amplification		 2-5% DNA sequencing