Table 2.

Genomic technologies for oncogene discovery

Genomic Approach	Type of Tumor Data
SNP Microarrays, Comparative Genomic Hybridization (CGH)	Chromosomal copy number
	Loss of heterozygosity
Gene Expression Microarrays	Gene expression profiles miRNA profiles
Sanger DNA Sequencing	Point mutations
	Small insertions and deletions
Mutation Profiling	Known and/or “druggable” mutations
Next-Generation DNA Sequencing	Point mutations
	Small insertions and deletions
	Chromosomal rearrangements translocations
	Chromosomal copy number
	DNA methylation (with bisulphite treatment)
	Epigenetics (with chromatin immunoprecipitation)
RNAi Screening	Essential genes
	Suppressor genes