Table 3.

Histology examination of kidney damage

Characteristicsa	Groups
	ZY	ZY+AG-490
Glomerular lesions	2.10 ± 0.10	0.50 ± 0.05**
Tubular vacuolization	4.90 ± 0.15	3.60 ± 0.10*
Tubular dilation	2.40 ± 0.10	1.50 ± 0.09*
Tubular necrosis	1.50 ± 0.05	0.50 ± 0.09*
Leukocyte infiltration	5.00 ± 0.20	2.95 ± 0.15**
Renal injury scoreb	15.00 ± 2.20	9.05 ± 2.15**

^aKidneys were collected on day 21 of zymosan injection from untreated (ZY) or treated with AG-490 (ZY+AG-490) mice.

^bThe renal injury score was calculated as an average score of the mean score for each characteristic. Data are calculated according to the examination of 30 sections/mice (n = 5/group) in 2 experiments. The results are expressed as mean ± SD and are compared by Student's t test. **p < 0.01 and *p < 0.05 versus zymosan-injected group.