Table 3.
Biomarkers of lipid peroxidation, antioxidant status, inflammation, insulinaemia and endothelial dysfunction in RA patients and controls.
| marker | controls | RA patients | p value |
| 8-IP | 0.659 (0.449–0.845) | 0.925 (0.598–1.248) | 0.004 |
| MDA | 3.195 (2.825–3.434) | 2.900 (2.648–3.346) | ns |
| selenium | 91.14 (84.12–101.3) | 84.55 (77.18–91.08) | 0.003 |
| TAC (ws) | 730.0 (586.9–888.0) | 728.2 (532.5–905.9) | ns |
| TAC (pfs) | 343.7 (292.2–394.9) | 334.7 (262.9–426.0) | ns |
| vitamin A | 2.714 (2.472–3.191) | 2.615 (2.241–3.224) | ns |
| vitamin E | 13.63 (11.91–16.53) | 13.41 (12.40–15.27) | ns |
| CRP | 3.025 (1.269–5.246) | 9.335 (5.201–11.79) | < 0.001 |
| IL-6 | 0.046 (0–0.398) | 3.723 (1.773–11.25) | < 0.001 |
| insulin | 6.65 (4.4–8.9) | 7.65 (5.9–11.4) | 0.035 |
| glucose | 4.700 (4.5–5.0) | 4.700 (4.4–5.1) | ns |
| HOMA-S | 0.718 (0.54–1.08) | 0.615 (0.40–0.80) | 0.039 |
| adiponectin | 3.369 (2.31–4.74) | 4.543 (3.15–6.97) | 0.012 |
| VCAM | 241.1 (200.4–260.8) | 253.8 (224.7–298.0) | 0.029 |
| E-selectin | 86.74 (54.19–107.3) | 113.4 (86.74–113.4) | < 0.001 |
| P-selectin | 17.34 (14.49–23.62) | 20.29 (16.47–25.40) | ns |
Results are expressed as median (interquartile range). The Mann-Whitney U test was used to calculate significance between groups. ns = not significant. Units were expressed as follows: 8-IP as ng/g creatinine; MDA and vitamin A as μmol/l; selenium, VCAM, E-selectin and P-selectin as μg/l; TAC (ws and pfs) as mmol/l trolox equivalents; vitamin E, CRP and adiponectin as mg/l; IL-6 as ng/l; insulin as mU/l; glucose as mmol/l.