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. 2009 Mar 20;136(8):1387–1396. doi: 10.1242/dev.028167

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Fig. 4. — Histological analyses of palate development in the control and Osr2-IresCre;Smo^c/c mutant embryos. (A,B) HE-stained frontal sections of E12.5 Osr2-IresCre;Smo^+/c (A) and Osr2-IresCre;Smo^c/c mutant (B) embryos showed comparable initial outgrowth of palatal shelves. (C,D) At E13.5, the palatal shelves of the Osr2-IresCre;Smo^c/c mutant embryo (D) appeared slightly retarded distally in comparison with the Osr2-IresCre;Smo^+/c embryo (C). (E,F) At E14.5, whereas the palatal shelves had elevated and initiated fusion at the midline in the control embryo (E), the palatal shelves of the Osr2-IresCre;Smo^c/c mutant embryo (F) appeared severely retarded and failed to contact each other. (G,H) Some Osr2-IresCre;Smo^c/c mutant embryos exhibited tissue protrusion into the nasopharynx, shown in H (marked by an asterisk), which was never observed in control embryos. p, palatal shelf; t, tongue.