Comparison of Bmp2, Bmp4, Msx1 and
Shox2 mRNA expression in the anterior palate of
Osr2-IresCre;Smo+/c and
Osr2-IresCre;Smoc/c mutant embryos at E13.5.
(A-F) In comparison with the control embryos, Bmp2 mRNA was
downregulated whereas Bmp4 and Msx1 mRNAs were upregulated
in the mutant anterior palatal mesenchyme. Arrowheads point to differences in
expression in the control (A,C,E) and mutant (B,D,F) palatal shelves.
(G,H) Shox2 mRNA expression was unaltered in the
Osr2-IresCre;Smoc/c mutant palate. p, palatal shelf; t,
tongue.