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. 2009 Mar 20;136(8):1387–1396. doi: 10.1242/dev.028167

Fig. 8.

Fig. 8.

Foxf1 and Foxf2 mRNA expression in the developing palate were downregulated in the Osr2-IresCre;Smoc/c mutant embryos. (A) At E13.5, Foxf1a mRNA was expressed in the anterior palatal mesenchyme underlying the lateral and medial edge epithelium (arrow) in the control embryos. (B) Foxf1a mRNA expression was specifically downregulated in the palatal mesenchyme but its expression in the tooth mesenchyme was not affected in the Osr2-IresCre;Smoc/c mutant embryos. Asterisks in A and B mark the maxillary first molar tooth buds. (C,D) At E13.5, Foxf1 mRNA expression in the posterior palate was restricted to more lateral and proximal cells in the control embryo (C) and this domain of expression (arrows in C and D) was also downregulated in the Osr2-IresCre;Smoc/c mutant embryos (D). (E-H) Foxf2 mRNA expression exhibited a lateral-to-medial gradient in both the anterior and posterior palate in the control embryos (E,G) and was downregulated in both the anterior and posterior palatal mesenchyme in the Osr2-IresCre;Smoc/c mutant embryos (F,H). E and F show anterior palates; G and H, posterior. p, palatal shelf; t, tongue.