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. 2009 Mar 20;136(8):1387–1396. doi: 10.1242/dev.028167

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Fig. 9. — Comparison of expression of Osr2, Pax9 and Fgf10 in the developing palate of the control and Osr2-IresCre;Smo^c/c mutant embryos. (A) At E13.5, Osr2 mRNA was strongly expressed in the mesenchyme lingual to the first molar tooth buds and exhibited a lateral-to-medial gradient in the palatal mesenchyme in control embryos. (B) In the Osr2-IresCre;Smo^c/c mutant embryos at E13.5, Osr2 mRNA expression was specifically downregulated in the palatal mesenchyme but the domain of expression in the lingual tooth mesenchyme was unaffected. (C,D) Pax9 mRNA expression in the developing palate and tooth mesenchyme was not affected in the Osr2-IresCre;Smo^c/c mutant embryos. (E,F) Fgf10 expression in the anterior palatal mesenchyme (arrows) was significantly downregulated in the Osr2-IresCre;Smo^c/c mutant embryos (F) in comparison with the control embryos (E). m, mandibular first molar tooth bud; p, palatal shelf.