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Partial HYAL1 and HYAL2 gene structures and mutation screening strategy. Exons are indicated by black boxes, introns are indicated by white boxes, and alternatively spliced exons are indicated by hatched boxes. Nucleotide numbering below the genes is based on the cDNA sequences. Fragments that were PCR-amplified for mutation analysis are labeled A through J and represent all of the transcribed regions of the gene that are protein encoding.
