Table 1.
Histoclinical correlations of breast cancers according to CD146 expression
| Characteristic | DNA microarray | Tissue microarray | ||
| CD146-rich (n = 113) | P value* | CD146+ (n = 45) | P value* | |
| Age | ||||
| < 45 years | 36/74 | NS | 9/85 | NS |
| ≥ 45 years | 59/115 | 36/549 | ||
| Pathological type | ||||
| Ductal | 92/179 | NS | 36/472 | NS |
| Lobular | 17/43 | 2/77 | ||
| Tubular | 1/40 | |||
| Medullar | 1/8 | |||
| Mixed | 2/25 | |||
| Other | 4/26 | |||
| Molecular subtype | ||||
| Basal | 44/67 | <0.0001 | ||
| ERBB2 | 15/31 | |||
| Luminal | 32/93 | |||
| Normal | 16/21 | |||
| Scarff Bloom and Richardson grade | ||||
| I + II | 26/77 | <0.0001 | 18/463 | <0.0001 |
| III | 87/149 | 27/163 | ||
| Tumor size | ||||
| < 20 | 28/53 | NS | 17/281 | NS |
| ≥ 20 | 54/122 | 26/347 | ||
| Pathological axillary lymph node status | ||||
| Negative | 52/90 | NS | ||
| Positive | 54/122 | |||
| Immunohistochemistry estrogen receptor status | ||||
| Negative | 72/119 | <0.0001 | 28/141 | <0.0001 |
| Positive | 41/108 | 13/460 | ||
| Immunohistochemistry progesterone receptor status | ||||
| Negative | 83/137 | <0.0001 | 35/208 | <0.0001 |
| Positive | 30/90 | 9/362 | ||
| Immunohistochemistry ERBB2 status | ||||
| Negative | 83/169 | NS | 40/515 | NS |
| Positive | 19/36 | 2/46 | ||
| Immunohistochemistry estrogen receptor/progesterone receptor/ERBB2 status | ||||
| Triple negative | 25/76 | <0.0001 | ||
| Other | 13/425 | |||
| Immunohistochemistry p53 status | ||||
| Negative | 14/330 | 0.0046 | ||
| Positive | 15/124 | |||
| Immunohistochemistry Bcl2 status | ||||
| Negative | 22/138 | <0.0001 | ||
| Positive | 18/388 | |||
| Immunohistochemistry CD44 status | ||||
| Negative | 1/136 | 0.0225 | ||
| Positive | 17/283 | |||
| Immunohistochemistry epithelial growth factor receptor status | ||||
| Negative | 3/284 | 0.00011 | ||
| Positive | 9/81 | |||
| Immunohistochemistry GATA3 status | ||||
| Negative | 30/203 | 0.00032 | ||
| Positive | 10/313 | |||
| Immunohistochemistry Moesin status | ||||
| Negative | 4/339 | <0.0001 | ||
| Positive | 13/65 | |||
| Immunohistochemistry P-cadherin status | ||||
| Negative | 1/199 | 0.00021 | ||
| Positive | 14/173 | |||
*To assess differences in clinicopathologic features between the two groups of patients, Fisher's exact test was used for qualitative variables with discrete categories.