. 2009 Feb 6;11(1):R8. doi: 10.1186/bcr2223

Table 3.

Model building steps

	Number of parameters	Akaike information criterion

		Both BRCA1 and BRCA2	BRCA1	BRCA2
Intercept	1	86.76	47.38	40.30
Sex	2	86.60	48.11	40.35
Proband breast cancer or ovarian cancer	2	87.75	48.37	41.22
Proband breast cancer	2	87.65	48.16	41.30
Proband bilateral breast cancer	2	87.62	48.32	41.06
Proband ovarian cancer	2	85.49	46.84	40.57
Family affected	2	86.19	45.05	41.29
Number of first-degree and second-degree relatives^a	2	87.45	47.93	41.26
Total number of family members affected^a	2	85.13	47.99	38.40
Proportion of family members affected^a	2	86.99	48.30	40.32
Total number of tumors (including bilateral)	2	83.58	47.93	36.24
Total number of breast tumors	2	87.46	47.82	38.90
Number of persons with bilateral cancer	2	87.23	48.17	38.61
Total number of ovarian tumors (tnot)	2	74.76	38.08	38.04
Number of persons with ovarian and/or breast tumors (nbot)	2	83.17	46.35	38.29
BRCAPRO score	2	67.36	35.90	33.74
Myriad score	2	69.17	36.84	34.25
Age at diagnosis (diag)	2	82.38	42.44	40.72
BRCAPRO + Myriad	3	66.30	35.55	33.30
BRCAPRO + Myriad + tnot	4	64.58	34.32	-
BRCAPRO + Myriad + tnot + diag	5	*62.46*	29.10	-
BRCAPRO + Myriad + tnot + diag + BRCAPRO:diag	6	-	28.29	-
BRCAPRO + tnot + diag + BRCAPRO:diag	5	-	*27.51*	-
BRCAPRO + Myriad + nbot	4	-	-	*33.16*

Bold numbers represent the univariate and multiple regression models with the lowest Akaike information criterion. Italic numbers represent univariate regressions models with Akaike information criterion lower than that of the corresponding model. ^aAffected families only.