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Stimulation of protein kinase B (Akt) by growth factors and mitogens in a pi3k (phosphoinositide 3 kinase)–dependent manner phosphorylates and subsequently destabilizes the tuberous sclerosis (Tsc1/Tsc2) complex. 10 pdk = pyruvate dehydrogenase kinase; mtor = mammalian target of rapamycin.
