Table 2.

Cytokines in supernatants of cultured spleen cells from mice treated with AndoSan™ or PBS p.o. before or after sensitization against OVA s.c..

Cytokine	Pre-OVA treatment	Post-OVA treatment
	AndoSan™/PBS index	AndoSan™/PBS index
IFNγ	1.13* ± 0.06	0.90* ± 0.11
IL-2	1.06*, ** ± 0.13	1.07 ± 0.00
IL-4	0.95 ± 0.15	0.82* ± 0.10
IL-5	0.83 ± 0.08	0.78 ± 0.05
IL-10	0.88* ± 0.08	0.89 ± 0.01

The indices are given as mean ± s.e.m. of 2–5 experiments in duplicates, each comprising 8 mice per group, of the highest read-out data of either OVA or Con A stimulated cultures for either 48 h or 72 h is given for each experiment. *In one of the experiments cytokine levels in supernatants of cell cultures from AndoSan™ treated mice were lower than from PBS treated mice (p < 0.05). **In one of the experiments cytokine levels in supernatants of cell cultures from AndoSan™ treated mice were higher than from PBS treated mice (p < 0.05). All over, indices for Th2 cytokines were lower than indices for Th1 cytokines (p = 0.026). The lack of data from some experiments is due to values below detection limit of assay.