Fig. 5.

Similarity of the WIPF1 and proliferation signatures. We determined average profiles (signature centroids) of the WIPF1 and the proliferation signatures in three data sets. Only 107 of 112 WIPF1 module genes with concordant lower expression in cluster X of the WIPF1 signature were considered for this analysis. Signature centroids were determined using averaging over all genes for each patient. The scatter plots visualize the strength of the correlation between proliferation signature and WIPF1 signature. Coordinates of each data point correspond to a single patient’s averaged mean-centered expression values for both signatures, a for the Staub colorectal cancer data set, b for the Wang breast cancer data set, and c for the Phillips glioma expression data set