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. 2009 Jun 8;4(6):e5821. doi: 10.1371/journal.pone.0005821

Figure 8. Knockdown of STAT1 using shRNA mitigates aggressive phenotype and restores sensitivity to doxorubicin.

Figure 8

(A) Number of lung colonies per mouse produced by control-transfected (P2M5A-MT) and shRNA knockdown (P2M5A-24 and P2M5A-26) cell lines. Shown are data for 2 (white bars) and 3 (gray bars) weeks after IV injection (mean±SEM). (B) Representative images of lungs, colonized by respective cell lines. (C) Caspase 3/7 activation as a measure of apoptosis in control (P2M5A-MT) and shRNA knockdown (P2M5A-24 and P2M5A-26) cells exposed to doxorubicin (1 µM) for 24 hours.