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. 2009 Jun 16;7(6):e1000130. doi: 10.1371/journal.pbio.1000130

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Fischer et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) A HOLE representation and an inset showing a close up view of the Aqy1 water channel constriction near Tyr31. (B) 2F _obs−F _calc electron density map (blue, contoured at 2.0 σ) and F _obs−F _calc electron density map (green, contoured at +2.2 σ) near Tyr31. Residual positive F _obs−F _calc electron density reveals electrons associated with protons participating in hydrogen bond interactions. (C) The N termini from the four subunits of the tetramer twist around each other and form an N-terminal bundle positioned on the cytoplasmic side of the membrane.