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. 2009 Jun 9;4(6):e5843. doi: 10.1371/journal.pone.0005843

Figure 3. Histological evaluation of the intratumoral microdistribution of the probe and VEGFR-2.

Figure 3

(a) The nanoprobes (shown in red) localized in the periphery of the tumor showing a patchy distribution (DAPI was used as a nuclear stain; shown in blue; 4× magnification). In the same slide, the highly vascularized peripheral rim is shown to have high levels of VEGFR-2 (shown in green) compared to the less vascularized inner core. (b) High intratumoral deposition of the nanoprobe is found in a region with high levels of VEGFR-2. (c) Relatively few nanoprobes accumulated in a region of low VEGFR-2 levels.